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KMID : 1098420170250050269
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Korean Journal of Medicinal Crop Science
2017 Volume.25 No. 5 p.269 ~ p.281
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Respiratory Protective Effect of Salvia plebeia R. Br. Extracts against Ambient Particulate Matter-induced Airway Inflammation
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Song Hyeong-Woo
Ji Kon-Young
Kim Bok-Kyu
Yang Won-Kyung
Han Chang-Kyun
Shin Han-Jae
Park Yang-Chun
Hwang Ki-Sook
Kang Hyung-Sik
Kim Seung-Hyung
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Abstract
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Background: Small particles increase airway inflammation upon reaching the alveoli. Here, we investigated the protective or therapeutic effects of Salvia plebeia R. Br. (SP_R) extracts on airway inflammation.
Methods and Results: To investigate the anti-inflammatory activity of SP_R extracts, we measured their inhibitory effect on the production of reactive oxygen species (ROS) expression of inflammatory mediators, and immune cell infiltration in MH-S alveolar macrophage cells and in the ambient particulate matter (APM)-exposed airway inflammation mice model. The SP_R extracts inhibited the production of ROS and expression of IL-4, IL-10, IL-15, and IL-17A mRNA in APM-stimulated MH-S cells. Oral administration of SP_R extracts suppressed APM-induced inflammatory symptoms, such as high alveolar wall thickness, excess collagen fibers, decreased mRNA expression of chemokines (Ccr9, Ccl5, Ccr3), inflammatory cytokines (IL-15, TNF-α), and IL-4 Th2 cytokine in the lung. The SP_R extracts also inhibited ROS production, granulocyte (CD11b+Gr-1+) infiltration, IL-17A, TNF-α, macrophage inflammatory protein (Mip-2), and chemokine (C-X-C motif) ligand 1 (Cxcl-1) production in the airway. The specific compounds in the SR-R extracts that mediate the anti-inflammatory effects were identified.
Conclusions: In this study, SP_R extracts effectively inhibited airway inflammatory responses, such as ROS production and granulocyte infiltration into the airway, by regulating the expression of chemokines and inflammatory cytokines.
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KEYWORD
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Salvia plebeia R. Br., Airway Inflammation, Ambient Particulate Matter, Chemokine, Reactive Oxygen Species
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